Publications

Refereed Articles

2024

  • Rui Y, Zhang M, Lee DMW, Snyder VC, Raghuraman R, Gofas-Salas E, Mecê P, Yadav S, Tiruveedhula P, Grieve K, Sahel JA, Errera MH, & Rossi EA. Label-free imaging of inflammation at the level of single cells in the living human eye. Ophthalmology Science 100475 (2024). DOI: 10.1016/j.xops.2024.100475.
  • Kari V. Vienola, John A. Holmes, Zolten Glasso, & Ethan A. Rossi. Head stabilization apparatus for high-resolution ophthalmic imaging. Appl. Opt. 63, 940-944 (2024). DOI: 10.1364/AO.513801.
  • Satcho E, Snyder VC, Dansingani KK, Liasis A, Kedia N, Gofas-Salas E, Chhablani J, Martel JN, Sahel JA, Paques M, Rossi EA, & Errera MH. Adaptive optics and multimodal imaging for inflammatory vitreoretinal interface abnormalities. Retina. In Press, accepted 1/3/2024.

    • 2023

  • Albrecht T, Mehmel B, Rossi EA, Trbovich A, Eagle S, Kontos AP. Temporal changes in fixational eye movements (FEMs) following concussion in adolescents and adults: Preliminary findings. J Neurotrauma. 2023 Aug 11. DOI: 10.1089/neu.2023.0080. PMID: 37565280.
  • Suthaharan S, Lee DMW, Zhang M & Rossi EA.Microsaccade segmentation using directional variance analysis and artificial neural networks. IEEE Computer Society 2023; 1-6. DOI: 10.1109/IRI58017.2023.00008.

    • 2022

  • Amarasekera S, Williams AM, Freund KB, Rossi EA, & Dansingani, KK. Multimodal imaging of multifocal choroiditis with adaptive optics ophthalmoscopy. Retinal Cases & Brief Reports. 2022; 16(6):747-753. DOI: 10.1097/ICB.0000000000001134. PMID: 36288621.
  • Vienola KV, Lejoyeux R, Gofas-Salas E, Snyder VC, Zhang M, Dansingani KK, Sahel J-A., Chhablani J, Rossi EA, Autofluorescent hyperreflective foci on infrared autofluorescence adaptive optics ophthalmoscopy in central serous chorioretinopathy. American Journal of Ophthalmology Case Reports 28, 101741 (2022). doi:10.1016/j.ajoc.2022.101741.
  • Gofas-Salas E, Rui Y, Mecê P, Zhang M, Snyder VC, Vienola KV, Lee D, Sahel JA, Grieve K, and Rossi EA, Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the inner retina in humans. BOE 13, 117-132 (2022). doi:10.1364/BOE.441808.

    • 2021

  • Vienola KV, Dansingani KK, Eller AW, Martel JN, Snyder VC, Rossi EA. Multimodal Imaging of Torpedo Maculopathy With Fluorescence Adaptive Optics Imaging of Individual Retinal Pigmented Epithelial Cells. Frontiers in Medicine 8 (2021): 2418. doi:10.3389/fmed.2021.769308
  • Rossi EA, Norberg N, Eandi C, Chaumette C, Kapoor S, Le L, Snyder VC, et al. A New Method for Visualizing Drusen and Their Progression in Flood-Illumination Adaptive Optics Ophthalmoscopy. Trans. Vis. Sci. Tech. 2021;10(14):19. doi:10.1167/tvst.10.14.19.
  • Leonard BT, Kontos AP, Marchetti GF, Zhang M, Eagle SR, Reecher HM, Bensinger ES, Snyder VC, Holland CL, Sheehy CK, Rossi EA. Fixational eye movements following concussion. JOV 2021;21(13):11. doi:10.1167/jov.21.13.11.
  • Vienola KV, Zhang M, Snyder VC, Dansingani KK, Sahel J-A, Rossi EA. Near infrared autofluorescence imaging of retinal pigmented epithelial cells using 663nm excitation. Eye (2021). doi:10.1038/s41433-021-01754-0.
  • Zhang M, Gofas-Salas E, Leonard BT, Rui Y, Snyder VC, Reecher HM, Mecê P, & Rossi EA. Strip-based digital image registration for distortion minimization and robust eye motion measurement from scanned ophthalmic imaging systems. BOE. 2021;12(4):2353–2372. doi:10.1364/BOE.418070.
  • Mecê P, Gofas-Salas E, Rui Y, Sahel JA, & Rossi EA. Spatial frequency-based image reconstruction to improve image contrast in multi-offset adaptive optics ophthalmoscopy. Optics Letters; 46(5):1085-1088. 2021; doi:10.1364/OL.417903.

    • 2020

  • Song H, Rossi EA, Williams DR. Reduced foveal cone density in early idiopathic macular telangiectasia. BMJ Open Ophthalmology 2021;6:e000603. doi: 10.1136/bmjophth-2020-000603.
  • Suthaharan S, Rossi EA, Snyder VC, et al. Laplacian feature detection and feature alignment for multimodal ophthalmic image registration using phase correlation and Hessian affine feature space. Signal Process. Published online 2020:107733. doi:https://doi.org/10.1016/j.sigpro.2020.107733
  • Vienola KV, Zhang M, Snyder VC, Sahel J-A, Dansingani KK, Rossi EA. Microstructure of the retinal pigment epithelium near-infrared autofluorescence in healthy young eyes and in patients with AMD. Sci Rep. 2020;10(1):9561. doi:10.1038/s41598-020-66581-x.

    • 2019

  • Song H, Rossi EA, Yang Q, Granger CE, Latchney LR, Chung MM. High-Resolution Adaptive Optics in Vivo Autofluorescence Imaging in Stargardt Disease. JAMA Ophthalmology. Published online March 21, 2019. doi:10.1001/jamaophthalmol.2019.0299.

    • 2018

  • Grieve K, Gofas-Salas E, Ferguson RD, Sahel JA, Paques M, & Rossi EA. In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation, Biomedical Optics Express. 2018 Dec 1; 9(12):5946-5961; doi: 10.1364/BOE.9.005946.
  • Granger CE, Yang Q, Song H, Saito K, Nozato K, Latchney LR, Leonard BT, Chung MM, Williams DR, & Rossi EA. Human retinal pigment epithelium: in vivo cell morphometry, multi-spectral autofluorescence, and relationship to cone mosaic. IOVS; 2018 Dec 3;59(15):5705-5716. doi: 10.1167/iovs.18-24677.
  • Song H, Rossi EA, Stone E, et al. Phenotypic diversity in autosomal-dominant cone-rod dystrophy elucidated by adaptive optics retinal imaging British Journal of Ophthalmology 2018;102:136-141. doi: 10.1136/bjophthalmol-2017-310498.
  • Williams ZW, Rossi EA, DiLoreto DA. In Vivo Adaptive Optics Ophthalmoscopy Correlated with Histopathologic Results in Cancer-Associated Retinopathy. Ophthalmology Retina. 2018 Feb; 2(2):143-151. doi: 10.1016/j.oret.2017.06.008.

    • 2017

  • Rossi EA, Granger CE, Sharma R, Yang Q, Saito K, Schwarz C, Walters S, Nozato K, Zhang J, Kawakami T, Fischer W, Latchney LR, Hunter JJ, Chung MM, Williams DR. Imaging individual neurons in the retinal ganglion cell layer of the living eye. Proceedings of the National Academy of Sciences of the United States of America. 2017 114 (3) 586-591. doi:10.1073/pnas.1613445114. PMID: 28049835.

    • 2015

  • Song H, Rossi EA, Latchney L, Bessette A, Stone E, Hunter JJ, Williams DR, Chung M. Cone and rod loss in Stargardt disease revealed by adaptive optics scanning light ophthalmoscopy. JAMA Ophthalmology. 2015 Oct;133(10):1198–203. PMID: 26247787.
  • Zhang J, Yang Q, Saito K, Nozato K, Roorda A, Williams DR, Rossi EA. An adaptive optics imaging system designed for clinical use. Biomedical Optics Express. 2015 Jun 1;6(6):2120. PMID: 26114033.
  • Yang Q, Yin L, Nozato K, Zhang J, Saito K, Merigan WH, Williams DR, Rossi EA. Calibration-free sinusoidal rectification and uniform retinal irradiance in scanning light ophthalmoscopy. Optics Letters. 2015 Jan 1;40(1):85. PMID: 25531615.

    • 2014

  • Yang Q, Zhang J, Nozato K, Saito K, Williams DR, Roorda A, Rossi EA. Closed-loop optical stabilization and digital image registration in adaptive optics scanning light ophthalmoscopy. Biomedical Optics Express. 2014 Sep 1;5(9):3174. PMID: 25401030.
  • Masella BD, Williams DR, Fischer WS, Rossi EA, Hunter JJ. Long-term reduction in infrared autofluorescence caused by infrared light below the maximum permissible exposure. Invest Ophthalmology & Visual Science. 2014 Jun;55(6):3929–38. PMID: 24845640.

    • 2013

  • Rangel-Fonseca P, Gómez-Vieyra A, Malacara-Hernández D, Wilson MC, Williams DR, Rossi EA. Automated segmentation of retinal pigment epithelium cells in fluorescence adaptive optics images. Journal of the Optical Society of America A. 2013 Nov 21; 30(12):2595. PMID: 24323021.
  • Rossi EA, Rangel-Fonseca P, Parkins K, Fischer W, Latchney LR, Folwell MA, Williams DR, Dubra A, Chung MM. In vivo imaging of retinal pigment epithelium cells in age related macular degeneration. Biomedical Optics Express. 2013 Nov 1;4(11):2527–39. PMID: 24298413.
  • Rossi EA, Achtman RL, Guidon A, Williams DR, Roorda A, Bavelier D, Carroll J. Visual Function and Cortical Organization in Carriers of Blue Cone Monochromacy. PLoS ONE. 2013 Feb 28;8(2):e57956. PMID: 23469117.

    • 2011

  • Rossi EA, Chung M, Dubra A, Hunter JJ, Merigan WH, Williams DR. Imaging retinal mosaics in the living eye. Eye (Lond). 2011 Mar;25(3):301-8. doi: 10.1038/eye.2010.221. PMID: 21390064.

    • 2010 and earlier

  • Rossi EA, Roorda A. Is visual resolution after adaptive optics correction susceptible to perceptual learning? Journal of Vision. 2010;10(12):11,1–14. PMID: 21047743.
  • Carroll J, Rossi EA, Porter J, Neitz J, Roorda A, Williams DR, Neitz M. Deletion of the X-linked opsin gene array locus control region (LCR) results in disruption of the cone mosaic. Vision Res. 2010 Sep 15;50(19):1989–99. PMID: 20638402.
  • Rossi EA, Roorda A. The relationship between visual resolution and cone spacing in the human fovea. Nature Neuroscience. 2010 Feb;13(2):156–7. PMID: 20023654.
  • Rossi EA, Weiser P, Tarrant J, Roorda A. Visual performance in emmetropia and low myopia after correction of high-order aberrations. Journal of Vision. 2007;7(8):14,1–14. PMID: 17685821.
  • Miller JM, Rossi EA, Wiesmair M, Alexander DE, Gallo O. Stability of gold bead tissue markers. Journal of Vision. 2006;6(5):616–24. PMID: 16881792.
  • Miller JM, Demer JL, Poukens V, Pavlovski DS, Nguyen HN, Rossi EA. Extraocular connective tissue architecture. Journal of Vision. 2003;3(3):240–51. PMID: 12723968.

    • Published Abstracts

  • Song H, Rossi EA, Latchney L, & Chung MM. Autofluorescence of the photoreceptors in Stargardt disease (SD) identified using fluorescence adaptive optics scanning light ophthalmoscopy (FAOSLO). Invest Ophthalmol Vis Sci. 2018; 59:4635.
  • Granger C, Williams DR, Rossi EA. Near-infrared autofluorescence imaging reveals the retinal pigment epithelial mosaic in the living human eye. Invest Ophthalmol Vis Sci. 2017; 58,3429.
  • Rossi EA, Sharma R, Granger C, Schwarz C, Yang Q, Hunter JJ, Williams DR. Individual inner retinal neurons imaged in the living eye of monkey and human. Invest Ophthalmol Vis Sci. 2016; 57(12).
  • Granger C, Song H, Yang Q, Saito K, Nozato K, Williams DR, Chung MM, Rossi EA. Contiguous mapping of retinal pigment epithelium (RPE) cell morphometry across the horizontal meridian of the living human eye. Invest Ophthalmol Vis Sci. 2016; 57(12).
  • Rossi EA, Saito K, Granger CE, Nozato K, Yang Q, Kawakami T, Zhang J, Fischer W, Williams DR, Chung MM. Adaptive optics imaging of putative cone inner segments within geographic atrophy lesions. Invest Ophthalmol Vis Sci. 2015 Jun 11;56(7):4931–4931.
  • Nozato K, Yang Q, Saito K, Suzuki K, Zhang J, Latchney LR, Williams DR, Rossi EA. Compact adaptive optics scanning light ophthalmoscope (AOSLO) with real-time optical stabilization and digital registration. Invest Ophthalmol Vis Sci. 2015 Jun 11;56(7):5977–5977.
  • Yang Q, Song H, Granger CE, Nozato K, Saito K, Zhang J, Latchney LR, Chung MM, Williams DR, Rossi EA. Safe real-time imaging of human retinal pigment epithelial cells in the living eye. Invest Ophthalmol Vis Sci. 2015 Jun 11;56(7):5971–5971.
  • Rossi EA, Song H, Latchney L, Folwell MA, Fischer W, Chung MM. Adaptive Optics Imaging of AREDS2 Patients Reveals a Variety of Photoreceptor Layer Morphologies. ARVO Meeting Abstracts. 2014 Apr 30;55(5):5236.
  • Yang Q, Zhang J, Nozato K, Saito K, Suzuki K, Williams DR, Rossi EA. Real-time optical stabilization and digital registration for high-resolution retinal imaging. Invest Ophthalmol Vis Sci. 2014 Apr 30;55(13):4815–4815.
  • Zhang J, Saito K, Yang Q, Nozato K, Suzuki K, Hunter JJ, Williams DR, Rossi EA. An integrated adaptive optics scanning light ophthalmoscope (AOSLO) and wide-field SLO (WF-SLO) for steerable high resolution retinal imaging. Invest Ophthalmol Vis Sci. 2014 Apr 30;55(13):5017–5017.
  • Saito K, Nozato K, Suzuki K, Roorda A, Dubra A, Song H, Hunter JJ, Williams DR, Rossi EA. Rods and cones imaged with a commercial adaptive optics scanning light ophthalmoscope (AOSLO) prototype. Invest Ophthalmol Vis Sci. 2014 Apr 30;55(13):1594–1594.
  • Nozato K, Yang Q, Saito K, Zhang J, Williams DR, Rossi EA. Automated correction of sinusoidal distortion and drift in resonant scanning retinal imaging systems. Invest Ophthalmol Vis Sci. 2014 Apr 30;55(13):1599–1599.
  • Hunter JJ, Masella BD, Fischer W, Rossi EA, Williams DR. Long-term reduction of infrared autofluorescence caused by infrared light below the maximum permissible exposure. Invest Ophthalmol Vis Sci. 2014 Apr 30;55(13):2172–2172.
  • Rangel-Fonseca P, Gomez-Vieyra A, Malacara-Hernandez D, Wilson M, Williams D, Rossi EA. Automated segmentation of retinal pigment epithelium cells in fluorescence adaptive optics images. Journal of Vision. 2013 Dec 27;13(15):P33–P33.
  • Rossi EA, Williams D, Dubra A, Latchney L, Folwell M, Fischer W, Song H, Chung M. Individual Retinal Pigment Epithelium Cells can be Imaged In Vivo in Age Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2013 Jun 16;54(15):6282–6282.
  • Chung M, Song H, Latchney L, Folwell M, Fischer W, Rossi EA. Cellular Features of Retinal Pigment Epithelial Atrophy after Regression of Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2013 Jun 16;54(15):6284–6284.
  • Song H, Pugliese A, Rossi EA, Latchney L, Stone E, Dubra A, Hunter J, Chung M. Adaptive Optics Scanning Laser Ophthalmoscopy in Stargardt Disease Reveals Decreased Cone and Rod Densities. Invest Ophthalmol Vis Sci. 2013 Jun 16;54(15):1743–1743.
  • Chung MM, Rossi EA, Song H, Dubra A, Gonzalez MO, Stone EM, Riley J, Williams DR. In vivo Adaptive Optics Imaging of the Cone Photoreceptor Mosaic in Autosomal Dominant Cone Rod Dystrophy (AD-CRD) in a Three-generation Family Carrying the I143NT Mutation in the Guanylate Cyclase Activator A1A (GUCA1A) Gene. Invest Ophthalmol Vis Sci. 2011 Apr 22;52(14):5002–5002.
  • Rossi EA, Achtman RL, Guidon A, Williams DR, Roorda A, Bavelier D, Carroll J. Visual Function and Cortical Organization in Carriers of Blue Cone Monochromacy. Invest Ophthalmol Vis Sci. 2010 Apr 17;51(13):6297–6297.
  • Song S, Rossi EA, Wickham C, Roorda A, Brillinger DR, Levi DM. Fixational eye movements for normal and strabismic amblyopic observers. Journal of Vision. 2010 Aug 6;10(7):456–456.
  • Rossi EA, Carroll J, Roorda A. The relationship between the cone photoreceptor mosaic and visual acuity in normal observers and blue cone monochromat carriers. Journal of Vision. 2010 Mar 28;8(17):20–20.
  • Rossi EA, Weiser P, Tarrant J, Roorda A. Does correction of higher order aberrations improve visual performance in myopes? Journal of Vision. 2010 Mar 28;6(13):63–63.
  • Rossi EA, Grieve K, Roorda A. Visual Acuity and the Photoreceptor Mosaic. Invest Ophthalmol Vis Sci. 2007 May 10;48(13):3175–3175.
  • Grieve KF, Tiruveedhula P, Rossi EA, Roorda A. Measuring Intrinsic Retinal Signals With the Adaptive Optics Scanning Laser Ophthalmoscope. Invest Ophthalmol Vis Sci. 2007 May 10;48(13):1954–1954.
  • Rossi EA, Roorda A. The Limits of High Contrast Photopic Visual Acuity with Adaptive Optics. Invest Ophthalmol Vis Sci. 2006 May 1;47(13):5402–5402.
  • Roorda A, Rossi EA, Zhang Y, Stevenson SB, Arathorn DW, Vogel CR, Parker A, Yang Q. Applications For Eye–Motion–Corrected Adaptive Optics Scanning Laser Ophthalmoscope Videos. Invest Ophthalmol Vis Sci. 2006 May 1;47(13):1808–1808.
  • Miller JM, Rossi EA, Konishi S, Abramoff MD. Visualizing Ocular Tissue Movement with Little Gold Beads. Invest Ophthalmol Vis Sci. 2003 May 1;44(13):3123–3123.
  • Miller JM, Demer JL, Poukens V, Pavlovski DS, Nguyen HN, Rossi EA. Extraocular Tissue Type Architecture. Invest Ophthalmol Vis Sci. 2002 Dec 1;43(13):1913–1913.

    • Patents

  • Rossi EA (sole inventor). METHOD FOR IMAGING RETINAL STRUCTURES. United States Patent No.: 10,772,496. Date: Sept. 15, 2020.
  • Rossi EA & Yang Q (co-inventors). SYSTEM AND METHOD FOR REAL-TIME MONTAGING FROM LIVE MOVING RETINA. United States Patent No.:10,226,173. Date: Mar. 12, 2019.
  • Rossi EA (sole inventor). APPARATUS AND METHOD FOR AUTOMATIC POSITION CONTROL IN AN OPTICAL SYSTEM AND APPLICATIONS. United States Patent No.: US 10,123,697. Date: Nov. 13, 2018.
  • Yang Q, Rossi EA. METHOD OF IMAGING MULTIPLE RETINAL STRUCTURES. United States Patent No.: US 10,092,181. Date: Oct. 9, 2018.