Our research is focused on studying the structure and function of the normal and diseased retina at the level of single cells in the living human eye. We use advanced optical imaging techniques with adaptive optics to study the cellular mosaics of the retina, from the retinal pigmented epithelial cells that line the back of the eye, to the photoreceptors that absorb light and initiate the first step of seeing, to the retinal ganglion cells whose parallel neural circuits process visual information and send it along to the rest of the brain. Visual function can be impaired when any of the different classes of cells in the retina are damaged or lost from causes such as genetic abnormalities, disease or trauma. Some specific diseases of focus for us include age-related macular degeneration, glaucoma, and inherited retinal degenerations ...

Current Projects

  • Imaging Retinal Ganglion Cells in Glaucoma
  • AMD
  • Concussion
  • Collaborators

  • UPMC Eye Center
  • Children’s Hospital of Pittsburgh
  • UPMC Sports Medicine Concussion Program
  • PARIS Group
  • Institut de la Vision
  • Roorda Lab
  • Advanced Retinal Imaging Alliance
  • University of North Carolina at Greensboro (UNCG)
  • Publications

    Recent publications

  • Gofas-Salas E, Rui Y, Mecê P, Zhang M, Snyder VC, Vienola KV, Lee D, Sahel JA, Grieve K, and Rossi EA, Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the inner retina in humans. BOE 13, 117-132 (2022). doi:10.1364/BOE.441808.
  • Vienola KV, Dansingani KK, Eller AW, Martel JN, Snyder VC, Rossi EA. Multimodal Imaging of Torpedo Maculopathy With Fluorescence Adaptive Optics Imaging of Individual Retinal Pigmented Epithelial Cells. Frontiers in Medicine 8 (2021): 2418. doi:10.3389/fmed.2021.769308.
  • Rossi EA, Norberg N, Eandi C, Chaumette C, Kapoor S, Le L, Snyder VC, et al. A New Method for Visualizing Drusen and Their Progression in Flood-Illumination Adaptive Optics Ophthalmoscopy. Trans. Vis. Sci. Tech. 2021;10(14):19. doi:10.1167/tvst.10.14.19.
  • Leonard BT, Kontos AP, Marchetti GF, Zhang M, Eagle SR, Reecher HM, Bensinger ES, Snyder VC, Holland CL, Sheehy CK, Rossi EA. Fixational eye movements following concussion. JOV 2021;21(13):11. doi:10.1167/jov.21.13.11.
  • Vienola KV, Zhang M, Snyder VC, Dansingani KK, Sahel J-A, Rossi EA. Near infrared autofluorescence imaging of retinal pigmented epithelial cells using 663nm excitation. Eye (2021). doi:10.1038/s41433-021-01754-0.

  • NEWS

    Recent News

    i2Eye 2021: Fourth Annual Autumn Course on Innovative Imaging in Eye Disease

    October 13-15, 2021 Pittsburgh, PA

    Recordings of the talks can be found here

    Recent News

    Fight for Sight/American Macular Degeneration Foundation 2021 Summer Student Fellowship Awarded to Terrence Ahlin

    Terrence is a second-year medical student at Lake Erie College of Osteopathic Medicine (LECOM). With support from these organizations, Terrence will be able to complete a project entitled An Improved Detection Scheme for Fluorescence Adaptive Ophthalmoscopy to Enable Quantification of Retinal Pigmented Epithelium Structure and Spectral Fluorescence in Aging and Age-Related Macular Degeneration.

    Spring 2021

    Manuscript "Strip-based digital image registration for distortion minimization and robust eye motion measurement from scanned ophthalmic imaging systems." has recently been accepted by Biomedical Optics Express. The corresponding source code will be released on our website soon.

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    University of Pittsburgh

    Address/ Location:

    Department of Ophthalmology
    University of Pittsburgh School of Medicine
    Eye & Ear Institute
    203 Lothrop St. Suite 834
    Pittsburgh. PA 15213
    Office: (412) 647-3745