Our research is focused on studying the structure and function of the normal and diseased retina at the level of single cells in the living human eye. We use advanced optical imaging techniques with adaptive optics to study the cellular mosaics of the retina, from the retinal pigmented epithelial cells that line the back of the eye, to the photoreceptors that absorb light and initiate the first step of seeing, to the retinal ganglion cells whose parallel neural circuits process visual information and send it along to the rest of the brain. Visual function can be impaired when any of the different classes of cells in the retina are damaged or lost from causes such as genetic abnormalities, disease or trauma. Some specific diseases of focus for us include age-related macular degeneration, glaucoma, and inherited retinal degenerations ...

Current Projects

  • Imaging Retinal Ganglion Cells in Glaucoma
  • AMD
  • Concussion
  • Collaborators

  • UPMC Eye Center
  • Children’s Hospital of Pittsburgh
  • UPMC Sports Medicine Concussion Program
  • PARIS Group
  • Institut de la Vision
  • Roorda Lab
  • Advanced Retinal Imaging Alliance
  • University of North Carolina at Greensboro (UNCG)
  • Publications

    Recent publications

  • Song H, Rossi EA, Yang Q, Granger CE, Latchney LR, Chung MM. High-Resolution Adaptive Optics in Vivo Autofluorescence Imaging in Stargardt Disease. JAMA Ophthalmology. Published online March 21, 2019. doi:10.1001/jamaophthalmol.2019.0299
  • Grieve K, Gofas-Salas E, Ferguson RD, Sahel JA, Paques M, & Rossi EA. In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation, Biomedical Optics Express. 2018 Dec 1; 9(12):5946-5961; doi: 10.1364/BOE.9.005946.
  • Granger CE, Yang Q, Song H, Saito K, Nozato K, Latchney LR, Leonard BT, Chung MM, Williams DR, & Rossi EA. Human retinal pigment epithelium: in vivo cell morphometry, multi-spectral autofluorescence, and relationship to cone mosaic. IOVS;2018 Dec 3;59(15):5705-5716. doi: 10.1167/iovs.18-24677.

  • NEWS

    Recent News

    Pavan Visits the Lab

    We were very pleased to have Pavan Tiruveedhula and his family visit us in Pittsburgh shortly after the new year. Pavan's software and hardware innovations for AOSLO and TSLO have been instrumental for our laboratory and it was truly an honor to welcome him to Pittsburgh.

    Recent News

    Fall 2019

    Rossi Lab gets recognition in UPMC Vision and Rehabilitation Tower Sneak Peek Article

    Recent News

    October 16, 2019

    Dr Rossi and staff presents their first Lunch and Learn funded by the WordOut grant they received in conjunction with the JCC AgeWell division. Three lunch and learn sessions will be held between now and the Spring of 2020- helping to inform and educate the community about vision research and the techniques/studies being used in Rossi Lab and within UPMC.

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    University of Pittsburgh

    Address/ Location:

    Department of Ophthalmology
    University of Pittsburgh School of Medicine
    Eye & Ear Institute
    203 Lothrop St. Suite 834
    Pittsburgh. PA 15213