Research

Our research is focused on studying the structure and function of the normal and diseased retina at the level of single cells in the living human eye. We use advanced optical imaging techniques with adaptive optics to study the cellular mosaics of the retina, from the retinal pigmented epithelial cells that line the back of the eye, to the photoreceptors that absorb light and initiate the first step of seeing, to the retinal ganglion cells whose parallel neural circuits process visual information and send it along to the rest of the brain. Visual function can be impaired when any of the different classes of cells in the retina are damaged or lost from causes such as genetic abnormalities, disease or trauma. Some specific diseases of focus for us include age-related macular degeneration, glaucoma, and inherited retinal degenerations ...

Current Projects

  • Imaging Retinal Ganglion Cells in Glaucoma
  • AMD
  • Concussion
  • Collaborators

  • UPMC Eye Center
  • Children’s Hospital of Pittsburgh
  • UPMC Sports Medicine Concussion Program
  • PARIS Group
  • Institut de la Vision
  • Roorda Lab
  • Advanced Retinal Imaging Alliance
  • University of North Carolina at Greensboro (UNCG)
  • Publications

    Recent publications

  • Vienola KV, Lejoyeux R, Gofas-Salas E, Snyder VC, Zhang M, Dansingani KK, Sahel J-A., Chhablani J, Rossi EA, Autofluorescent hyperreflective foci on infrared autofluorescence adaptive optics ophthalmoscopy in central serous chorioretinopathy. American Journal of Ophthalmology Case Reports 28, 101741 (2022). doi:10.1016/j.ajoc.2022.101741.
  • Gofas-Salas E, Rui Y, Mecê P, Zhang M, Snyder VC, Vienola KV, Lee D, Sahel JA, Grieve K, and Rossi EA, Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the inner retina in humans. BOE 13, 117-132 (2022). doi:10.1364/BOE.441808.
  • Vienola KV, Dansingani KK, Eller AW, Martel JN, Snyder VC, Rossi EA. Multimodal Imaging of Torpedo Maculopathy With Fluorescence Adaptive Optics Imaging of Individual Retinal Pigmented Epithelial Cells. Frontiers in Medicine 8 (2021): 2418. doi:10.3389/fmed.2021.769308.
  • Rossi EA, Norberg N, Eandi C, Chaumette C, Kapoor S, Le L, Snyder VC, et al. A New Method for Visualizing Drusen and Their Progression in Flood-Illumination Adaptive Optics Ophthalmoscopy. Trans. Vis. Sci. Tech. 2021;10(14):19. doi:10.1167/tvst.10.14.19.

  • NEWS

    Vision Walk

    Vision Walk : Pittsburgh Chapter

    October 29th, 2022

    Dr Rossi along with Dr Ian Conner were the medical co-chairs for this year's 15th annual Vision Walk. A yearly event sponsored by the Foundation Fighting Blindness Pittsburgh chapter, held at the Great Lawn in Pittsburgh's North Side. The Foundation’s goal is to drive the research that will lead to preventions, treatments, and vision restoration for the spectrum of degenerative retinal diseases, specifically macular degeneration – including age related macular degeneration, retinitis pigmentosa, Usher syndrome, Stargardt disease and Leber congenital amaurosis (LCA). Together these conditions affect more than 10 million Americans and millions more throughout the world. During its now 50-year history, the Foundation has raised over $856 million in support of its effort to reverse blindness and restore vision. To learn more about the foundation please visit :https://www.fightingblindness.org

    Recent News

    NVIDIA Hardware Grant Received Spring 2022

    Rossi Lab staff members Min Zhang and Daniel Lee recently demonstrated a clear understanding of how to use NVIDIA technology (RTX A5000 GPU) to accelerate the labs research and significantly impact the success of many AI, data science, and imaging registration projects on the horizon.

    Recent News

    February 2022

    Rossi Lab in conjunction with the UPMC Concussion group is first to precisely evaluate fixational eye movements in patients following concussion. Recent results published in Journal of Vision featured in the US Department of Defense (DoD) Blast Injury Research Coordinating Office Research Highlights, Pittsburgh Post-Gazette and Inside UPMC

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    SUPPORT

    Pitt

    University of Pittsburgh

    Address/ Location:

    Department of Ophthalmology
    University of Pittsburgh School of Medicine
    Eye & Ear Institute
    203 Lothrop St. Suite 834
    Pittsburgh. PA 15213
    Office: (412) 647-3745